Reprogramming protein degradation

Molecular glue degraders are frontline anti-cancer agents and herald extraordinary promise for degrader drug development. The target-drug-E3 ligase ternary complexes enforced by small molecule degraders are our starting point for synthetic biology development. We are learning to chemically and genetically retarget protein degradation machinery in order to control immune cell programming in new and therapeutically impactful ways. By advancing clinically suitable tools composed of human proteins and FDA-approved small molecules, we envision a platform for direct clinical translation.